Progesterone receptor modulators.

نویسنده

  • Ruzva Bhathena
چکیده

The review1 on ‘Progesterone receptor modulators in gynaecological practice’ in the April 2010 issue of the Journal is a valuable contribution to the available literature on a currently important subject. In the section on ‘Contraception’ the authors have dealt at length with mifepristone. Since the latter is not licensed for postcoital contraception, it would have been appreciated if the authors had dealt with some salient features of the recently introduced second-generation selective progesterone receptor modulator, ulipristal acetate, which is licensed for postcoital contraception for up to 120 hours after unprotected sexual intercourse. The primary mechanism of action is inhibition of ovulation, but alterations in the endometrium also have anti-implantation effects.2 Ulipristal acetate appears to be a more potent inhibitor of ovulation than levonorgestrel and hence may be relatively more effective as a method of postcoital contraception.3–5 While the post-implantation use of levonorgestrel has not been associated with any harm to an early pregnancy, as yet the same has not been established for ulipristal acetate.6

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عنوان ژورنال:
  • The journal of family planning and reproductive health care

دوره 36 3  شماره 

صفحات  -

تاریخ انتشار 2010